目的报道肾透明细胞癌颅骨转移1例。方法对1例影像学上诊断不明确的左枕部病灶行手术切除,明确病理为肾透明细胞癌颅骨转移,并复习相关文献。结果患者行左枕部病灶切除后送病理检查明确诊断该颅骨病灶为肾透明细胞癌。结论本病例为单发转移癌,手术切除为有效的治疗方法,确诊需靠病理检查,术后积极探明并治疗原发灶。 Objective To report a case of renal clear cell carcinoma skull metastasis. Methods One case of left occipital lesion with unclear diagnosis on imaging was surgically excised, and the clear pathology was skull metastasis of clear cell renal cell carcinoma, and the related literatures were reviewed. Results The patient underwent left occipital lesion resection and sent pathology to confirm the diagnosis of clear skull lesions of renal clear cell carcinoma. Conclusion This case of single metastatic cancer, surgical resection is an effective treatment, the diagnosis required by pathological examination, positive exploration and treatment of primary lesions after surgery.