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目的观察乳癌基因1(BRCA1)在鼻咽癌中的表达水平并分析其表达水平与预后的关系。方法采用免疫组化S-P法检测100例患者鼻咽癌组织中BRCA1蛋白的表达水平,阳性细胞计数≥50%定为BRCA1高表达组;<50%及不表达者定为BRCA1低表达组。应用χ2检验对BRCA1表达水平与临床资料进行关联性分析。结果 100例患者中13例失访,BRCA1高表达者37例(42.5%),低表达者50例(57.5%);BRCA1表达与患者的临床分期(P=0.383)、原发灶退缩情况(P=0.434)、肿瘤发生远处转移(P=0.055)无明显关联性,高表达组生存率稍高于低表达组,但差异无统计学意义(P>0.05)。结论鼻咽癌组织中BRCA1蛋白的表达与临床分期和原发灶退缩程度无关,但BRCA1低表达者更易出现远处转移的趋势。
Objective To observe the expression of breast cancer gene 1 (BRCA1) in nasopharyngeal carcinoma (NPC) and to analyze its relationship with prognosis. Methods The expression of BRCA1 protein in 100 cases of nasopharyngeal carcinoma was detected by immunohistochemical S-P method. The positive cell count≥50% was defined as BRCA1 overexpression group; Χ2 test was used to analyze the correlation between BRCA1 expression level and clinical data. RESULTS: Thirteen of 100 patients were lost to follow-up. There were 37 cases (42.5%) with BRCA1 overexpression and 50 cases (57.5%) with low BRCA1 expression. The expression of BRCA1 was correlated with the clinical stage (P = 0.383) P = 0.434). No significant correlation was found between the distant metastasis of tumor (P = 0.055). The survival rate of high expression group was slightly higher than that of low expression group, but the difference was not statistically significant (P> 0.05). Conclusion The expression of BRCA1 protein in nasopharyngeal carcinoma has no relation with the clinical stage and the extent of primary lesion. However, the expression of BRCA1 in nasopharyngeal carcinoma is more likely to have distant metastasis.