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目的探讨中药对肝硬化大鼠肝细胞调亡、NO和NOS活性的影响。方法在建立大鼠肝硬化模型的基础上,检测了肝细胞调亡率和血液中的内毒素水平,以及肝组织中NOS活性和血液中NO含量,并同时观察中药治疗肝硬化后上述指标的变化。结果治疗组大鼠肝细胞凋亡率和血清中内毒素水平较对照组有显著降低（P＜0.05）,肝组织中NOS活性也有显著下降（P＜0.05）,同时血液中NO含量显著下降（P＜0.05）。结论中药治疗肝硬化,控制了内毒素的过量产生,使肝细胞凋亡下降,组织中NOS活性相应减弱,继而释放NO的量减少,有利于肝硬化的好转与恢复。
Objective To investigate the effects of Chinese herbs on hepatocyte apoptosis, NO and NOS activity in cirrhotic rats. Methods On the basis of establishing a model of liver cirrhosis in rats, the apoptosis rate of hepatocytes and endotoxin level in blood were measured, and the activity of NOS in liver tissue and NO level in blood were detected. Meanwhile, the above indexes Variety. Results Compared with the control group, the apoptosis rate of liver cells and the level of endotoxin in the serum of the treated group were significantly decreased (P <0.05) and the activity of NOS in the liver tissue of the treated group was significantly decreased (P <0.05), while the content of NO in the blood was significantly decreased P <0.05). Conclusion Chinese medicine treatment of liver cirrhosis, controlling the overproduction of endotoxin, hepatocellular apoptosis decreased, NOS activity correspondingly weakened in the organization, followed by the release of NO decreased, is conducive to the improvement and recovery of liver cirrhosis.