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近年来随着人们物质生活水平的提高,高血压、血脂异常、糖尿病、吸烟、肥胖等心血管疾病的危险因素逐渐增多,动脉粥样硬化性心血管疾病已经成为现在人类主要死亡原因之一。众所周知,他汀类药物是治疗高血脂疾病的首选药物,随着科研的进步,越来越多的实验数据表明,他汀类药物具有独立的降压作用,它主要通过改善细胞内皮功能,下调血管紧张素Ⅰ型受体,调节细胞色素P450酶的代谢途径从而达到降压的效果。
In recent years, with the improvement of people’s living standards, risk factors of cardiovascular diseases such as hypertension, dyslipidemia, diabetes, smoking, obesity gradually increase, atherosclerotic cardiovascular disease has become one of the major causes of human death. As we all know, statin drugs for the treatment of hyperlipidemia drug of choice, with the progress of scientific research, more and more experimental data show that statins have an independent antihypertensive effect, which is mainly through the improvement of endothelial function, down regulation of vascular tone Type Ⅰ receptor, regulating the metabolic pathway of cytochrome P450 enzymes in order to achieve the effect of antihypertensive.