肾性蛋白尿的发生机理目前尚不十分清楚。许多学者认为,肾小球电荷屏障功能的破坏可能是重要原因。因此,研究肾小球的电荷屏障功能在各种肾脏疾病中的变化已是当今肾脏病学界的重要课题。本文就近年来国内外有关研究肾小球电荷屏障的方法及其各自的特点作一简介。一、肾小球的固定阴电荷肾小球的固定阴电荷是构成肾小球电荷屏障的基础。目前认为,肾小球的固定阴电荷是由几个部分组成。最早发现的是位于肾小球上皮细胞及内皮细胞被膜表面的一层带阴电荷的涎 The mechanism of renal proteinuria is not yet clear. Many scholars believe that the destruction of glomerular charge barrier function may be an important reason. Therefore, the study of the glomerular charge-barrier function in a variety of kidney diseases has become an important issue in the current nephrology. This article in recent years at home and abroad to study the method of glomerular charge barrier and their respective characteristics as an introduction. First, the glomerular fixation Yin charge Glomerular fixation Yin charge constitutes the basis of the glomerular charge barrier. It is currently believed that the fixed glomerulus charge is composed of several parts. The first discovery is located in the glomerular epithelial cells and endothelial cells on the surface of a layer of membrane with negative charge