论文部分内容阅读
目的：探讨尼群地平对心肌电生理特性的影响及药理学机制，为该药在临床应用上的推广提供基础理论依据。方法：采用常规微电极技术观察尼群地平对离体豚鼠乳头状肌快反应动作电位、收缩力的影响。结果：尼群地平对快Ｎａ＋通道无作用（Ｐ＞０．０５），对平台期慢Ｃａ２＋通道有双重效应（Ｐ＜０．０１）。结论：尼群地平有抑制慢Ｃａ２＋通道的作用同时对缺血性心肌有保护作用
Objective: To investigate the effect of nitrendipine on electrophysiological characteristics of myocardium and its pharmacological mechanism, and provide a theoretical basis for the promotion of this drug in clinical application. Methods: Conventional microelectrode technique was used to observe the effect of nitrendipine on the action potential and contractility of guinea pig papillary muscles. Results: Nitrendipine had no effect on fast Na + channel (P> 0.05), but had a dual effect on slow plateau Ca2 + channel (P <0.01). CONCLUSION: Nitrendipine can inhibit the slow Ca2 + channel and protect the ischemic myocardium at the same time