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目的分析78例宫颈癌根治性放疗所致的放射性直肠损伤的临床资料。方法对78例病人采用60Co高剂量率腔内后装照射加60Co或8MVX直线加速器全盆腔照射加盆腔四野照射。结果发生直肠反应38例,占35.89%,发生放射性直肠炎12例,占15.38%。根据体外放疗单次剂量的不同及照射总剂量不同进行比较,差异有高度显著性(P<0.01)。结论照射总剂量、时间-剂量类型、是否铺助化疗是导致放射性直肠损伤的主要因素。
Objective To analyze the clinical data of 78 cases of radiation-induced rectal injury caused by radical radiotherapy of cervical cancer. Methods 78 cases of patients with 60Co high dose rate intracavity after irradiation plus 60Co or 8MVX linear accelerator plus pelvic four field irradiation. Results Rectal reaction occurred in 38 cases, accounting for 35.89%, 12 cases of radiation proctitis, accounting for 15.38%. According to the difference of single dose of external radiotherapy and the total dose of irradiation, the difference was highly significant (P <0.01). Conclusion The total dose of radiation, time-dose type, whether chemotherapy-assisted chemotherapy is the main factor leading to radioactive rectal injury.