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目的探讨尿微量蛋白如α1-微球蛋白(α1-MG)、β2-微球蛋白(β2-MG)、微量白蛋白(mAlb)、免疫球蛋白G(IgG)和N-乙酰-β-D-氨基葡萄苷酶(NAG)对慢性阻塞性肺病患者肾脏损害的早期诊断价值。方法以60例健康青壮年和健康老年人为正常对照组,95例慢性阻塞性肺病(COPD)根据是否合并呼吸衰竭分为2组。所有受试者留晨尿10ml离心,收集上清液,检测尿四项微量蛋白和NAG。结果老年组尿α1-MG、β2-MG与健康青壮年对照组有差异(P<0.05),其余各项指标无差异(P>0.05);单纯COPD组患者,尿α1-MG、β2-MG、mAlb与健康青壮年对照组和老年组有显著性差异(P<0.01),尿NAG和IgG尿和IgG与上述两组无显著性差异(P>0.05);COPD合并呼吸衰竭组患者,尿NAG和α1-MG、β2-MG、mAlb、IgG与其余三组组比较均有显著性差异(P<0.01)。结论尿微量蛋白和NAG可作为慢性阻塞性肺病肾脏损害的早期诊断指标。
Objective To investigate the effects of urinary microalbumin such as α1-MG, β2-MG, mAlb, IgG and N-acetyl-β-D Early Diagnostic Value of Aminoglucosidase (NAG) on Renal Damage in Patients with Chronic Obstructive Pulmonary Disease. Methods Sixty healthy young adults and healthy elderly people as normal control group, 95 cases of chronic obstructive pulmonary disease (COPD) were divided into two groups according to whether they were combined with respiratory failure. All subjects were left morning urine 10ml centrifuged, the supernatant was collected, urine test four trace proteins and NAG. Results Urine α1-MG, β2-MG and healthy young adults in the elderly group were significantly different (P <0.05), and there was no difference in other indicators (P> 0.05) (P <0.01), urine NAG and IgG, urine IgG and IgG had no significant difference with the above two groups (P> 0.05). Patients with COPD complicated with respiratory failure, urine NAG and α1-MG, β2-MG, mAlb, IgG and the other three groups were significantly different (P <0.01). Conclusion Urine microalbumin and NAG can be used as early diagnosis indicators of renal damage in chronic obstructive pulmonary disease.