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目的:糖尿病周围神经病变是糖尿病最常见的并发症,我们对治疗2型糖尿病周围神经病变的有效方法进行了偿试。方法:将66例2型糖尿病周围神经病变患者随机分为两组。在常规应用口服降糖药或胰岛素治疗的基础上,治疗组加用弥可保500μg肌注每周3次,前列腺素E1100μg加入生理盐水250 mL中静脉滴注,每日1次;对照组加用维生素B12500μg肌注每周3次,复方丹参注射液20 mL加入生理盐水250 mL中静脉滴注,每日1次,疗程均为4周。结果:治疗组总有效率82.3%,与对照组比较差异有显著性(P<0.05)。临床症状改善方面,治疗组肢体麻木、肢体疼痛改善率分别达72%和75%,明显高于对照组的37%和44%,感觉减退、多汗、口干、腹泻、便秘、排尿障碍改善也优于对照组(分别为53%比26%、51%比16%、53%比19%、57%比26%、51%比28%、61%比26%)。结论:弥可保与前列腺素E1合用治疗糖尿病周围神经病变是一种有效的方法。
PURPOSE: Diabetic peripheral neuropathy is the most common complication of diabetes mellitus, and we validated an effective method of treating type 2 diabetic peripheral neuropathy. Methods: 66 patients with type 2 diabetic peripheral neuropathy were randomly divided into two groups. In the conventional application of oral hypoglycemic agents or insulin treatment, based on the treatment group plus Mi Kebao 500μg intramuscular injection three times a week, prostaglandin E1100μg added 250 ml of normal saline intravenously once daily control group plus Vitamin B12500μg intramuscular injection three times a week, compound Danshen injection 20 mL added 250 mL of normal saline intravenously once a day for 4 weeks. Results: The total effective rate in the treatment group was 82.3%, which was significantly different from that in the control group (P <0.05). In terms of improvement of clinical symptoms, numbness and limb pain in the treatment group were improved by 72% and 75%, respectively, which were significantly higher than those in the control group (37% and 44% respectively). The symptoms of hyponatremia, hyperhidrosis, dry mouth, diarrhea, constipation and dysuria were improved Also better than the control group (53% vs. 26%, 51% vs. 16%, 53% vs. 19%, 57% vs. 26%, 51% vs. 28%, 61% vs. 26%, respectively). Conclusion: Combination of methycobal and prostaglandin E1 in the treatment of diabetic peripheral neuropathy is an effective method.