【摘 要】
：
Objective:Cheongseoikki-tang(CIT,Korean),also called Qingshu Yiqi decoction(清暑益气汤)and Seisho-ekki-to(Japanese),is well known as an effective traditional co
【机 构】
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College of Pharmacy and Wonkwang Oriental Medicines Research Institute,Wonkwang University,Jeonbuk(5
【出 处】
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Chinese Journal of Integrative Medicine
论文部分内容阅读
Objective:Cheongseoikki-tang(CIT,Korean),also called Qingshu Yiqi decoction(清暑益气汤)and Seisho-ekki-to(Japanese),is well known as an effective traditional combination of herbs for treating cardiovascular diseases.This study was to research its effects on bone marrow-derived mast cell(BMMC)-mediated allergy and inflammation mechanisms.Methods:In this study,the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated,focusing on its effects on the production of allergic mediators by phorbol 12-myristate 13-acetate(PMA) plus calcium ionophore A23187(A23187)-stimulated BMMCs.These allergic mediators included interleukin-6(IL-6),prostaglandin D_2(PGD_2),leukotriene C_4(LTC_4),andβ-hexosaminidase(β-hex).Results:Our data revealed that CITE inhibited the production of IL-6,PGD_2,LTC_4,andβ-hex induced by PMA plus A23187 (P<0.05).Conclusion:These findings indicate that CITE has the potential for use in the treatment of allergy.
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