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肝肾综合征患者的肾功能障碍可在接受肝移植后得到恢复。胰升糖素和胰岛素具有滋肝作用,二者并用可改善肝脏功能,甚至使已硬化的肝脏出现肝细胞再生。基于以上事实,作者用胰升糖素和胰岛素治疗14例肝硬化患者以观察对肝硬化腹水患者肾功能的治疗作用。7例患者有腹水和下肢水肿(失代偿组);7例无腹水和水肿(代偿组),作为对照组。所有病例均经肝活检证实。试验期间,患者每天的热卡、水份和食物中氯化钠的摄入量分别为30 kcal/kg、1000ml和5 g。用药前摄入氯化钠5g/d,至少观察7天,然后以胰升糖素1U和普通胰岛素10U加入10%葡萄糖液500ml内静脉滴注2小时滴毕,每天1次,共14天。治疗前后分别测定SGPT、SGOT、血浆蛋白、胆红素、凝血酶原时间、血栓形成试验、吲哚氰绿
Renal dysfunction in patients with hepatorenal syndrome can be restored after undergoing liver transplantation. Glucagon and insulin have the role of nourishing the liver, the two can be used to improve liver function, and even cirrhosis of liver regeneration occurred. Based on the above facts, the authors treated 14 patients with cirrhosis with glucagon and insulin to observe the therapeutic effect of renal function in patients with cirrhosis and ascites. Seven patients had ascites and lower extremity edema (decompensation group); 7 patients had no ascites and edema (compensatory group), as the control group. All cases were confirmed by liver biopsy. During the trial, patients daily calorie intake, water and food intake of sodium chloride were 30 kcal / kg, 1000ml and 5g. Inhalation of sodium chloride before treatment 5g / d, at least observed for 7 days, and then with glucagon 1U and ordinary insulin 10U 10% glucose solution 500ml intravenous drip two hours, 1 day, a total of 14 days. Before and after treatment were measured SGPT, SGOT, plasma protein, bilirubin, prothrombin time, thrombosis test, indocyanine green