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目的探讨血清幽门螺杆菌(Hp)抗体对消化性溃疡患者的临床意义。方法选取幽门螺杆菌感染的消化性溃疡患者298例,免疫印迹法检测血清Hp抗体,分析抗体阳性表达情况与不同消化性溃疡患者的关系。结果在消化性溃疡的现症患者中,Hp抗体以Ⅰ型为主,阳性率为77.85%,显著高于Ⅱ型抗体阳性率,差异有统计学意义(P<0.01)。十二指肠溃疡HpⅠ型抗体阳性率高于胃溃疡,差异有统计学意义(P<0.05)。HpⅠ型感染者中以CagA+VacA抗体为主,阳性率为79.74%;各组中CagA+VacA抗体阳性率显著高于单一的CagA或VacA抗体阳性率,差异均有统计学意义(P<0.01)。结论 Hp血清学检测对消化性溃疡患者的诊断和治疗均有重要临床指导意义,Ⅰ型Hp菌株抗体阳性的患者更应得到临床重视。
Objective To investigate the clinical significance of serum Helicobacter pylori (Hp) antibody in patients with peptic ulcer. Methods 298 cases of peptic ulcer patients infected with Helicobacter pylori were selected. Serum Hp antibodies were detected by Western blotting. The relationship between antibody positive expression and different peptic ulcer patients was analyzed. Results Among the patients with peptic ulcer, the positive rate of Hp antibody was type I (77.85%), which was significantly higher than that of type II antibody (P <0.01). The positive rate of Hp Ⅰ antibody in duodenal ulcer was higher than that in gastric ulcer, the difference was statistically significant (P <0.05). The positive rate of CagA + VacA antibody in Hp Ⅰ infection was 79.74%. The positive rate of CagA + VacA antibody in each group was significantly higher than that of single CagA or VacA antibody (P <0.01) ). Conclusion Serological tests of Hp have important clinical significance in the diagnosis and treatment of patients with peptic ulcer. Patients with positive type I Hp strains should receive clinical attention.