对40例孕妇行硬膜外麻醉下剖宫产手术,术中静脉应用氯胺酮,以期达到镇静、镇痛及减轻内脏牵拉反应,就其对产妇呼吸循环功能的影响进行观察。结果:应用氯胺酮后全部产妇意识消失、血压上升、SpO_2下降、4例发生呼吸抑制。提示氯胺酮作为硬膜外麻醉辅助用药有镇静、镇痛、改善阻滞效果、减轻牵拉反应、兴奋循环作用,但亦可引起通气不足及呼吸抑制,应用时需注意。 Forty pregnant women underwent cesarean section under epidural anesthesia and intraoperative intravenous ketamine in order to achieve sedation, analgesia and visceral traction response, and to observe their effects on maternal respiratory cycle. Results: All ketamine disappeared, blood pressure increased, SpO_2 decreased, and respiratory depression occurred in 4 patients. It is suggested that ketamine, as an adjunct to epidural anesthesia, may have sedative and analgesic effects, improve the retardation effect, reduce the pulling reaction and stimulate the circulation, but may also cause hypoventilation and respiratory depression.