KL-6是一种人类MVC-1粘蛋白,主要存在于正常人肺的Ⅱ型细胞和细支气管上皮细胞上。血清和支气管灌洗液中的KL-6是评价间质性肺炎和肺纤维化病情活动性的敏感指标。一部分肺结核患者因肺损害发展成严重的呼吸功能障碍、呼吸衰竭和肺心病,主要是因为胸膜纤维性增厚和广泛的肺纤维化合并肺气肿。作者对肺结核患者血清KL-6含量进行了测定,结合临床资料分析其对肺损害程度的预示价值。 KL-6 is a human MVC-1 mucin that is found mainly in type II cells and bronchiolar epithelial cells in normal human lung. KL-6 in serum and bronchial lavage fluid is a sensitive indicator of disease activity in interstitial and pulmonary fibrosis. Some patients with tuberculosis developed severe respiratory dysfunction, respiratory failure and pulmonary heart disease due to lung damage, mainly because of pleural fibrosis and extensive pulmonary fibrosis with emphysema. The authors measured the content of serum KL-6 in patients with pulmonary tuberculosis, combined with clinical data to predict its value of lung damage.