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目的观察地特胰岛素对口服降糖药(PAD)控制不佳的2型糖尿病(T2DM)患者临床疗效。方法 33例OAD血糖控制不佳的T2DM患者,加用地特胰岛素每日睡前皮下注射,共24周。观察用药前后FBG、2hBG、HbA_1c、BMI等的变化。结果治疗后T2DM患者FBG、2hBG、HbA_1c均明显下降(P<0.01)。日间低血糖发生率9.1%,无夜间症状性低血糖发生,体重无明显增加。结论 OAD控制不佳的T2DM患者加用地特胰岛素可有效控制血糖,低血糖发生率低,体重增加不明显。
Objective To observe the clinical effect of detemir on type 2 diabetes mellitus (T2DM) patients with poorly controlled oral hypoglycemic agents (PAD). Methods Thirty-three T2DM patients with poor OAD blood glucose control were treated with detemir daily at bedtime for 24 weeks. Before and after treatment FBG, 2hBG, HbA_1c, BMI and other changes. Results After treatment, FBG, 2hBG and HbA 1c in T2DM patients were significantly decreased (P <0.01). The incidence of hypoglycemia during the day 9.1%, no night hypoglycemia, no significant increase in body weight. CONCLUSION: Dextrins can effectively control blood glucose in T2DM patients with poor OAD control. The incidence of hypoglycemia is low and body weight gain is not significant.