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果蝇作为一种模式生物,具有生命周期短、繁殖力强、基因保守性高等特点。目前,果蝇已广泛应用于药理学和疾病机制研究中,涵盖衰老、神经退行性疾病、失眠、肿瘤等领域,在加快药物筛选速度和靶点发现等方面显示出潜在的应用价值。笔者就果蝇作为模式生物的优势、在药理学研究中的应用及局限性3个方面展开综述。
Drosophila as a model organism, with a short life cycle, fertility, gene conservative features. Currently, fruit flies have been widely used in the study of pharmacology and disease mechanisms, covering the fields of aging, neurodegenerative diseases, insomnia and cancer, and have shown potential applications in speeding up drug screening and target discovery. The author of Drosophila as a model organism advantage in the pharmacology of the application and limitations of three aspects are reviewed.