论文部分内容阅读
用ＥＬＩＳＡ测定１８１例各型ＨＢＶ感染者血请中ＨＤＶ标志物，结果ＨＤＶＭ阳性５７例，阳性率为３１．４９％。各型肝炎间ＨＤＶ感染卒的差异有显著性（Ｐ＜０．０５），依次为ＳＨ＞ＬＣ＞ＣＡＨ＞ＣＰＨ＞ＡＨ＞ＡＳＣ。用异羟基洋地黄毒试元标记的ＨＢＶＤＮＡ探针测定其中５７例ＨＢＶ／ＨＤＶ及单纯ＨＢＶ感染病人血清中ＨＢｖＤＮＡ及其含量，结果ＨＢＶＤＮＡ的检出率在ＨＢＶ／ＨＤＶ组（６７．９２％）明显低于单纯ＨＢＶ感染组（８４．６２％）（Ｐ：０．０１５２），且前组中ＨＢＶＤＮＡ含量也明显低于后组（Ｐ＜０．０５）。以上结果提示：ＨＤＶ感染多见于严重的及慢性肝脏疾病；在ＨＢＶ／ＨＤＶ感染的急性期，ＨＢＶ复制受到抑制；而在重症型、慢性期和肝硬化时则未见这种抑制现象，说明在ＨＢＶ／ＨＤＶ感染的不同阶段可表现出不同的病毒复制现象。
The serum HDV markers in 181 cases of HBV infection were detected by ELISA. The results showed that HDVM was positive in 57 cases, the positive rate was 31.49%. There was a significant difference in the severity of HDV infection among various types of hepatitis (P <0.05), followed by SH> LC> CAH> CPH> AH> ASC. The HBV DNA and its content in serum of 57 patients with HBV / HDV and simple HBV infection were detected by HBD DNA probe labeled with digoxigenin, and the detection rate of HBVDNA was significantly higher in HBV / HDV group (67.92%) (84.62%) (P = 0.0152), and the content of HBVDNA in the former group was significantly lower than that in the latter group (P <0.05). The above results suggest that: HDV infection is more common in severe and chronic liver diseases; in the acute phase of HBV / HDV infection, HBV replication is inhibited; while in severe, chronic and cirrhosis, this inhibition is not found, Different stages of HBV / HDV infection can exhibit different viral replication phenomena.