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目的讨论阳江高本底地区群组研究不同阶段的资料合并与癌症危险的统计分析。方法调查分阶段进行，１９７０～１９７８年为回顾性调查，１９７９～１９８６年为动态人群前瞻性观察，１９８７～１９９５年为定群研究，后两个阶段的数据已经计算机化。采用记录连接方法进行１９７９～１９８６年和１９８７～１９９５年随访数据的合并。危险分析基于详细的人年列表，分组变量包括性别、到达年龄（ａｔｔｅｎｄｅｄａｇｅ）、随访年份和剂量分组。利用标准的Ｐｏｉｓｓｏｎ回归方法估计超额相对危险和与对照组相比高本底地区每个剂量组的相对危险。采用似然比χ２近似方法计算显著性检验的双侧Ｐ值和９５％置信区间。结果由于某些成员的出生日期在两个随访阶段数据库中有所不同及其他原因，约有１０％的群组成员未能完成记录连接。我们讨论了合并随访数据的三种方法。结论癌症危险分析基于１９７９～１９９５年记录连接合并资料，包括１２５０７９人，累计观察１６９８３５０人年，１０４１５人死亡，其中１００３人为癌症死亡。癌症危险估计的结果将有另文专门讨论。
Objective To discuss the statistical analysis of data consolidation and cancer risk in different stages of cohort study in Yangjiang high background area. Methods The investigation was carried out in stages. From 1970 to 1978, a retrospective survey was conducted. From 1979 to 1986, prospective population observation was conducted. From 1987 to 1995, population-based studies were conducted. The data of the latter two stages were computerized. Record-joining methods were used to combine the follow-up data from 1979 to 1986 and from 1987 to 1995. Hazard analysis is based on a detailed list of people years, grouped variables including gender, age at age, follow-up years, and dose grouping. Standard Poisson regression was used to estimate the relative risk of excess relative risk and each dose group in the high background area compared to the control group. Two-sided P values and 95% confidence intervals for the significance test were calculated using the likelihood ratio χ2 approximation. Results About 10% of the group members failed to complete the record connection because some members’ birth dates were different in the two follow-up databases and for other reasons. We discussed three ways to incorporate follow-up data. Conclusions Cancer risk analysis was based on records of mergers and acquisitions from 1979 to 1995, including 125,079 people, with a total of 1,698,350 person-years and 10415 deaths, of whom 1003 were cancer deaths. The results of the cancer risk assessment will be specifically discussed elsewhere.