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目前,药物治疗胃溃疡的问题尚未解决,保守治疗后有50%的患者复发。胼胝性穿透性溃疡多合并炎性浸润,使胃切除术不能完成。作者采用抗代谢药物——5-氟脲嘧啶和氨甲喋呤治疗胼胝性胃溃疡获得成功。其作用机制在于:炎症增生过程存在正常的细胞分化加速现象,5-氟脲嘧啶具有抑制快速分化细胞核酸生成的作用,从而减轻和抑制炎症过程。5-氟脲嘧啶治疗急性胰腺炎已有报导。作者观察,这类药物对胼胝性溃疡病的疗效尤为显著。方法是用淋巴管造影术在足淋巴管注入氨甲喋
At present, the problem of drug treatment of gastric ulcer has not been resolved, and 50% of patients relapse after conservative treatment. Penetrating penetrating ulcers often contain inflammatory infiltrates that prevent gastrectomy. The authors succeeded in treating spastic gastric ulcers with 5-fluorouracil and methotrexate, an antimetabolite. The mechanism of action is that there is a normal acceleration of cell differentiation during inflammatory hyperplasia, and 5-fluorouracil has the effect of inhibiting the production of rapidly differentiated cell nucleic acids, thereby alleviating and inhibiting the inflammatory process. 5-Fluorouracil treatment of acute pancreatitis has been reported. The authors observe that these drugs are particularly effective for spastic ulcer disease. The method is to use lymphangiography to inject vaginosis into the lymphatics of the foot