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CeO2是一种常见的催化材料,具有很高的实用及研究价值.人们在其形貌的可控合成以及催化活性的调节等方面进行了大量的研究,取得了很多成果.近年来,随着纳米材料生物应用研究的兴起,纳米氧化铈在生物抗氧化领域的应用受到了越来越多的关注.在纳米尺度下,由于表面氧缺陷的产生,氧化铈中部分Ce4+被还原为Ce3+以稳定缺陷.此时材料中的Ce3+和Ce4+能够可逆的转化,这一性质使得纳米CeO2能够催化分解生物体内的过量自由基,从而为治疗氧化应激类疾病提供了一种可能.本综述对纳米CeO2的生物抗氧化作用进行了总结,重点讨论了CeO2纳米颗粒的抗氧化机理以及影响其生物效应的关键因素,还介绍了纳米CeO2生物安全性相关的一些研究,并对其生物应用前景进行了展望.
CeO2 is a common catalytic material with high practicality and research value.Here many studies have been made on the controlled synthesis of its morphology and the regulation of catalytic activity and many achievements have been made.With the rapid development of The application of nanomaterials in biological applications has attracted more and more attentions on the applications of nanocrystalline cerium oxide in the field of biological anti-oxidation.In the nanoscale, some Ce4 + in cerium oxide is reduced to Ce3 + due to the surface oxygen defects Defects .In this case, Ce3 + and Ce4 + in the material can be reversibly transformed. This property makes CeO2 nano-catalyze the decomposition of excess free radicals in vivo, thus providing a possibility for the treatment of oxidative stress diseases. The biological antioxidation of CeO2 nanoparticle has been discussed in detail. The antioxidant mechanism of CeO2 nanoparticle and the key factors that affect the biological effect of CeO2 nanoparticle have also been discussed. Some researches on the biological safety of CeO2 nanopowder have also been introduced, and the prospect of their biological application has been prospected .