苄氧基常用于保护羟基,其后再将苄基切断以恢复原来的羟基。催化氢化是最常用的脱去苄基的方法。但当苄氧基处于不同的化学结构中时,氢化的难易有很大的差别,有时甚至无法进行,需采取其它的氢解方法。本文报告几类核苷类衍生物的氢解反应,并比较化学结 Benzyloxy groups are often used to protect the hydroxyl group, followed by cleavage of the benzyl group to restore the original hydroxyl group. Catalytic hydrogenation is the most commonly used method for removing benzyl groups. However, when the benzyloxy groups are in different chemical structures, hydrogenation difficulties are quite different and sometimes can not be carried out. Other hydrogenolysis methods are required. This article reports the hydrogenolysis of several classes of nucleoside derivatives and compares chemical reactions