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目的：采用缩窄腹主动脉造成压力负荷性心肌肥厚大鼠模型，观察血管紧张素转换酶抑制剂陪多普利早期给药对心室重构的预防作用以及相应的心肌组织病理学改变。方法：大鼠分三组，正常对照组、心肌肥厚组和陪多普利治疗组。治疗组在模型制备手术后即开始给药至１２周。心肌组织ＨＥ染色和胶原ＶＧ 染色，图像分析系统测量心肌细胞横径（ＴＤＭ）、心肌胶原容积分数（ＩＣＶＦ）和血管周围胶原面积（ＰＶＣＡ）。结果：在压力负荷增加致心肌肥厚过程中，同时有心肌细胞和间质胶原二方面重构改变；陪多普利早期给药能明显减轻心肌细胞和间质胶原重构发生。结论：早期使用陪多普利对压力负荷心室重构有一定的预防作用
OBJECTIVE: To observe the preventive effect of early administration of the paracetamol, an angiotensin converting enzyme inhibitor, on ventricular remodeling and the corresponding changes of myocardial histopathology in a rat model of myocardial hypertrophy caused by narrowing the abdominal aorta. Methods: Rats were divided into three groups, normal control group, cardiac hypertrophy group and the treatment group. The treatment group began to be administered to 12 weeks after the model preparation procedure. Myocardial tissue HE staining and collagen VG staining, image analysis system to measure myocardial cell diameter (TDM), myocardial collagen volume fraction (ICVF) and perivascular collagen area (PVCA). Results: During myocardial hypertrophy induced by increased pressure load, both cardiomyocytes and interstitial collagen remodeling changed. Early administration of escitalopril could significantly reduce the remodeling of myocardial cells and interstitial collagen. Conclusion: Early use of escitalopril can prevent ventricular remodeling under pressure