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目的:观察臭氧仪联合硝酸咪康唑软胶囊迅速缓解重度外阴阴道念珠菌病(VVC)临床症状的效果。方法:100例患者随机分为两组。联合治疗组50例,给予硝酸咪康唑(达克宁)软胶囊1.2 g×3粒(分1、4、7天入阴道后穹窿)(伊曲康唑口服200 mg/天×2天(臭氧仪治疗1次/天×1天;单纯药物治疗组50例,给予达克宁软胶囊1.2 g×3粒(分1、4、7天入阴道后穹窿)(伊曲康唑口服200 mg/天×2天。结果:联合治疗组治疗总有效率达100%,临床症状迅速缓解率(1天)为66%;单纯药物治疗组治疗总有效率达98%,临床症状迅速缓解率(1天)为32%,两组临床症状迅速缓解率差异有统计学意义(2χ=11.56,P<0.01)。结论:臭氧仪联合达克宁栓治疗VVC,症状缓解快且治疗效果好,安全、无毒副作用,操作方便,患者依从性较好。
Objective: To observe the effect of ozonizer combined with miconazole nitrate soft capsule in rapidly relieving the clinical symptoms of severe vulvovaginal candidiasis (VVC). Methods: One hundred patients were randomly divided into two groups. 50 patients in the combination therapy group were given 1.2 g × 3 capsules of miconazole nitrate (subcutaneouly into the vaginal fornix after 1,4 and 7 days) (oral administration of itraconazole 200 mg / day × 2 days Treatment 1 times / day × 1 day; 50 cases of simple drug treatment group, giving soft capsule 1.2 g × 3 tablets (points 1,4,7 days into the vaginal fornix) (Itraconazole oral 200 mg / day × 2 Day.Results: The total effective rate of the combination therapy group was 100%, the rapid clinical symptom relief rate was 66% (one day); the total effective rate of the simple drug therapy group was 98%, the rapid clinical symptom relief rate was (2χ = 11.56, P <0.01) .Conclusion: Ozone meter combined with dacronide suppository in the treatment of VVC has the advantages of quick response and good curative effect, safe, non-toxic and side effects, operation Convenient, patient compliance is better.