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轻型阿弗它溃疡是一种小的、复发性、中度疼痛的溃疡,主要侵犯非角化口腔粘膜。其发生原因不明,至今没有安全、有效的治疗药物。本文选择1335例轻型复发性阿弗它溃疡患者(均有1~3个溃疡,出现时间不长于48h),采用赋形剂对照、随机、双盲、各组并行。多中心计计方法,对一种新型口腔药物1%和5%Amlexanox口腔糊剂促进溃疡愈合和消除疼痛效果进行了论证。 结果表明:1%和5%Amlexanox均比赋形剂能较好地减小溃疡大小,5%优于1%的Amlexanox,它比赋形剂和未治疗者能更大程度地促进溃疡愈合和减轻疼痛。 Amlexanox是2氨基-7异丙基-5氧-5H(1)苯吡喃基-(2,3-b)-吡啶-3石炭酸二甲苯酸,也称作CHX-3673,是用于治疗慢性哮喘的药物,具有抗过敏和抗炎
Light Aphrodit's ulcer is a small, recurrent, moderately painful ulcer that primarily affects non-keratinizing oral mucosa. Its causes are unknown, so far no safe and effective treatment of drugs. In this paper, 1335 patients with mild recurrent aphthous ulcer (1 ~ 3 ulcers in all, the appearance of time is not longer than 48h), using vehicle control, randomized, double-blind, parallel to each group. A multicenter clinical trial demonstrated the efficacy of a 1% and 5% Amlexanox buccal cavity paste for ulcer healing and pain relief. The results showed that 1% and 5% Amlexanox both reduced ulcer size better than vehicle, Amlexanox 5% better than 1%, which promoted ulcer healing to a greater extent than vehicle and vehicle Reduce pain. Amlexanox is 2 amino-7-isopropyl-5-oxo-5H (1) benzopyranyl- (2,3-b) -pyridine-3 phenyldicarboxylate, also known as CHX-3673, Asthma medication with anti-allergy and anti-inflammatory