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体外反搏作为无创伤性辅助循环装置,由于可显著提高主动脉舒张压,治疗某些缺血性疾病,尤其是对缺血性心脏病的治疗,已在临床得以广泛开展。体外反搏在治疗上有经济、无副作用、安全、效果明显等特点,其他化学药物难以媲美。现就体外反搏治疗冠心病作用原理的有关问题阐述如下。一、体外反搏对“冬眠心肌”的影响缺血心肌再灌流的预后与缺血时间的长短有密切关系。动物实验表明,在短暂缺血后,闭塞的冠状动脉重新开放,常引起该区组织血流过度灌注,称为反应性充血。反应只限于短暂缺血(数秒或数分钟)区,缺血组织的缺血、缺氧情况得以改善,代谢及功能完全恢复。反应性充血现象可用“冬眠心
As a noninvasive auxiliary circulatory device, extracorporeal counterpulsation has been widely used clinically because it can significantly increase aortic diastolic pressure and treat some ischemic diseases, especially for the treatment of ischemic heart disease. EECP in the treatment of economic, no side effects, safety, the effect is obvious, and other chemical drugs is difficult to rival. Now on the principle of extracorporeal counterpulsation in the treatment of coronary heart disease related issues are described below. First, the extracorporeal counterpulsation on the ”hibernating myocardium,“ the impact of ischemic myocardial reperfusion and the prognosis of ischemic time is closely related to the length of time. Animal experiments show that after a brief ischemia, the occluded coronary arteries are reopened, often causing over-perfusion of blood flow in the area, called reactive hyperemia. Response was limited to transient ischemia (seconds or minutes) area, ischemic tissue ischemia, hypoxia was improved, the metabolism and function fully restored. Reactive congestion phenomenon available ”hibernation heart