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近年来发现含铝制酸剂能妨碍体内钙磷代谢,并导致骨骼的病理改变。铝可以在肝脏、肌肉、骨骼、甲状旁腺及脑等多种组织沉积,且与更年期痴呆症(Alzheimer氏病)及尿毒性脑病的发病有关。摄入铝的有害作用遂被重视。据报导制酸剂中等铝可被肠道吸收并与磷相结合,抑制磷的吸收,明显增加粪便磷的排出。与此同时还增加尿中钙排出。研究表明甚至长期小剂量应用氢氧化铝也能造成严重的骨痛、软骨病、假性骨折。大剂含铝制酸剂可致血磷和尿磷降低,尿钙增加。钙
In recent years, found that aluminum containing acid can hinder the body of calcium and phosphorus metabolism, and lead to pathological changes in bone. Aluminum can be deposited in many tissues such as liver, muscle, bone, parathyroid and brain, and is associated with the development of menopausal dementia (Alzheimer’s disease) and uremic encephalopathy. The harmful effects of aluminum intake have been taken seriously. It is reported that the medium acid aluminum can be absorbed by the intestine and combined with phosphorus, inhibit the absorption of phosphorus, significantly increase the excretion of fecal phosphorus. At the same time also increase urinary calcium excretion. Studies have shown that even low-dose long-term use of aluminum hydroxide can cause severe bone pain, osteomalacia, pseudo-fractures. Large agent containing aluminum can cause decreased blood phosphorus and urinary phosphate, increased urinary calcium. calcium