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目的：探讨鼻内翻性乳头状瘤与人类乳头状瘤病毒（ＨＰＶ）的关系。方法：对２２例鼻窦和鼻腔的内翻性乳头状瘤标本分别进行免疫组织化学染色和ＰＣＲ检测。结果：２２例标本中，经免疫组织化学方法检出ＨＰＶ阳性细胞的有１１例，ＰＣＲ方法检出ＨＰＶＤＮＡ的共１７例。ＨＰＶ分型结果发现以ＨＰＶ１１、１６型最多，且以混合性感染为主。其中２例非典型增生的病例为ＨＰＶ１１／１６感染，１例复发病例为ＨＰＶ１１／１８型感染。结论：ＨＰＶ感染在鼻内翻性乳头状瘤的发生发展中具有重要地位，而且可能为一早期事件，ＨＰＶ１６、１８型与鼻内翻性乳头状瘤的复发及癌变有关。在检测上，ＰＣＲ方法优于免疫组织化学染色，值得提倡和推广。
Objective: To investigate the relationship between nasal inverted papilloma and human papillomavirus (HPV). Methods: Twenty-two specimens of inverted papilloma of the sinuses and nasal cavity were detected by immunohistochemistry and PCR respectively. Results: Of the 22 specimens, HPV positive cells were detected by immunohistochemistry in 11 cases, and HPV DNA was detected by PCR in 17 cases. HPV typing results found that most of HPV11, type 16, and mainly mixed infections. Two cases of atypical hyperplasia were HPV11 / 16 and one case of recurrence was HPV11 / 18. Conclusion: HPV infection plays an important role in the occurrence and development of nasal inverted papilloma, and may be an early event. HPV16 and 18 are associated with the recurrence and carcinogenesis of nasal inverted papilloma. In the detection, PCR method is superior to immunohistochemical staining, it is worth promoting and promoting.