一、对晶体蛋白抗原性的认识长期以来,晶体蛋白被认为与身体免疫系统“完全隔开”,是一种“非己”的蛋白。一旦进入循环系统、则可引起免疫反应,导致自身免疫性损害。关于晶体蛋白具有抗原性问题,首由Uhlerhan(1903)进行了研究。他用牛晶体反复免疫家兔,兔所产生的抗体与多种动物的晶体提取物产生反应,而与牛的血清不产生反应。从而认为晶体抗原具有器官特异性,而没有种族特异性。这种观点几十年来一直被大多数人所接受。 First, the understanding of the antigenicity of the crystal protein For a long time, the crystal protein is considered “completely separate” from the body’s immune system and is a “non-self” protein. Once inside the circulatory system, it can cause an immune response, leading to autoimmune damage. Regarding the antigenicity of crystal proteins, first studied by Uhlerhan (1903). He repeatedly immunized rabbits with bovine crystals, the antibodies produced by rabbits reacted with the crystal extracts of various animals, but did not react with the bovine serum. The crystal antigens are thus considered to be organ specific without racial specificity. This view has been accepted by most people for decades.