Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction re

来源 :Journal of Zhejiang University-Science B(Biomedicine & Biote | 被引量 : 0次 | 上传用户:ewenxj860411
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective:To evaluate whether liposomal prostaglandin E1 (lipo-PGE1) can decrease reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction (AMI).Methods:Twenty-two male Chinese mini-swines were randomized into three groups:six in a sham-operation group,and eight each in the control and lipo-PGE1 groups.The distal part of the left anterior descending coronary artery (LAD) in the latter two groups was completely occluded for 2 h,and then reperfused for 3 h.Lipo-PGE1 (1 μg/kg) was injected 10 min before LAD occlusion until reperfusion for 1 h in the lipo-PGE1 group.Hemodynamic data and proinflammatory cytokines were examined before AMI,2 h after occlusion,and 1,2,and 3 h after reperfusion.Myocardial contrast echocardiography (MCE) and double staining were performed to evaluate the myocardial no-reflow area (NRA).Results:Left ventricular systolic pressure and end-diastolic pressure significantly improved in the lipo-PGE1 group after reperfusion compared with the control group and also 2 h after AMI (P<0.05 for both).MCE and double staining both showed that lipo-PGE1 decreased reperfusion NRA after AMI (P<0.05,P<0.01).Lipo-PGE1 decreased serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) after myocardial infarction reperfusion (P<0.05 for both).Conclusions:Lipo-PGE1 is cardioprotective in our porcine model of myocardial infarction reperfusion no-reflow,decreasing NRA and attenuating the inflammatory response. Objective: To evaluate whether liposomal prostaglandin E1 (lipo-PGE1) can decrease reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction (AMI). Methods: Twenty-two male Chinese mini-swines were randomized into three groups: six in a sham-operation group, and eight each in the control and lipo-PGE1 groups. distal part of the left anterior descending coronary artery (LAD) in the latter two groups were completely occluded for 2 h, and then reperfused for 3 Lipo-PGE1 (1 μg / kg) was injected 10 min before LAD occlusion until reperfusion for 1 h in the lipo-PGE1 group. Hemodynamic data and proinflammatory cytokines were examined before AMI, 2 h after occlusion, and 1,2, Results: Left ventricular systolic pressure and end-diastolic pressure significantly improved in the lipo-PGE1 group after reperfusion (MCE) and double staining were performed to evaluate the myocardial no-reflow area compared with the control group and also 2 h after AMI (P <0.05 for both) .MCE and double-staining both showed that lipo-PGE1 decreased reperfusion NRA after AMI (P <0.05, P <0.01) .Lipo-PGE1 decreased serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) after myocardial infarction reperfusion (P <0.05 for both). Conclusions: Lipo-PGE1 is cardioprotective in our porcine model of myocardial infarction reperfusion no-reflow, attenuating the inflammatory response.
其他文献
在9月公测后好评不断的《三国群英传》,已确定在11月进行首度全面改版啰!全新开放的城池、前所未见的高阶新技能、新敌对军团的强势入侵……许许多多惊奇的新增功能,保证要让
1904年5月21日,国际足联在法国巴黎成立。1921年3月1日,法国人雷米特当选为国际足联第三任主席,正是在他的努力下,举办世界杯的梦想得以成为现实,而雷米特因此被称为世界杯
国家自然科学基金重点项目“杉木桉树人工林长期生产力保持机制研究”于 2 0 0 2年 3月2 2日经国家自然科学基金委生命科学部组织验收 ,评价为“A”级。参加此次验收的专家有
本文着重介绍了用二氧化碳和酒精混合作冷却剂的制冷原理,和应用于机械设备检修中的冷装工艺过程。方法简单,冷装时间短,技术、经济效果显著。对于机械制造和设备检修冷装工
吉卜赛人散布在世界各地。他们四处流浪,没有固定的家园,生活与那永无止境的道路一起不断向前延伸。他们的理想是充分享受漫步的自由与快乐、在无尽的星光下安然入梦。这个
“山径绿林得,溪声树底闻。香传千里竹,绿浸半身云……”清人国梁所描写的芦草沟、大草滩一带田园牧歌式的风光已经难觅踪影。那时,这里芦荻萧萧,荒草凄凄,野兽出没;如今,这
2005年9月28日,北京奥组委执行副主席兼秘书长王伟在外国专家大厦为在京工作的外国专家们做了一场主题为2008年北京奥运的专题报告会,生动翔实地介绍了北京奥运会的筹备计划
在铁帽上进行铅同位素测量,是勘探“层控”Pb-Zn-Cu矿床的一种手段.此法基于层控矿体的均匀同位素成分,基于其比率与所谓的“生长曲线”密切的拟合.这二者也是表征原生硫化
黄河水黄,黄河水长,九曲十八弯奔腾在三晋大地上。管声悠悠,管声悲怆,如泣如诉回荡在黄土高原上。忻州市北路梆子①剧团、忻州师范学院艺术系联合演出的现代戏《黄河管子声》
上海台网的浙江横湖、大洋山观测点及佘山地震台等,分别建立在山区和海岛的偏僻地方。台站上的地震仪所记录到的地震信号,通过PTY-8地震遥测设备传送至上海台网记录中心。过