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目的探讨血清Ⅲ型前胶原氨基端肽(PⅢNP)的浓度与肝硬化的关系。方法采用化学发光法检测血清Ⅲ型前胶原氨基端肽(PⅢNP)的浓度。结果各种病因肝硬化患者及其Child各级患者PⅢNP水平均明显高于正常组,且肝硬化Child A、B、C患者PⅢNP水平差异也存在着显著性。结论血清PⅢNP水平在一定程度上可以反映肝硬化患者的综合肝功能状态,对评价肝硬化患者预后有一定的临床意义。
Objective To investigate the relationship between the serum level of procollagen aminoterminal peptide (PⅢNP) and cirrhosis. Methods The level of serum procollagen aminoterminal peptide (PⅢNP) was detected by chemiluminescence method. Results The levels of PⅢNP in cirrhotic patients and their Child patients with various causes were significantly higher than those in normal controls. There was also significant difference in PⅢNP levels between Child A, B and C patients with cirrhosis. Conclusion The level of PⅢNP in serum can reflect the comprehensive state of liver function in patients with cirrhosis to a certain extent, which has some clinical significance for evaluating the prognosis of patients with liver cirrhosis.