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三氧化二砷是中药砒石的主要成分,治疗急性早幼粒细胞白血病已获得满意疗效,其完全缓解率在初治患者达73%,复发患者也达52%,最长缓解期超过10 a.本药静脉给药为宜,不产生明显毒副作用,并且在治疗白血病时与其他化疗药之间无交叉耐药性.为进一步拓展药用价值,扩大其肿瘤谱及临床治疗应用谱,我们探讨三氧化二砷对人肝癌细胞株生长的抑制作用及其机制,为其用于肝癌治疗提供理论依据.1 材料和方法1.1 材料人肝癌细胞株 BEL-7402由哈尔滨医科大学公卫学院李洪源老师惠赠.三氧化二砷由哈尔滨医科大学第一临床
Arsenic trioxide is the main component of traditional Chinese medicine vermiculite. It has achieved satisfactory curative effect in the treatment of acute promyelocytic leukemia. The complete remission rate reaches 73% in newly diagnosed patients, 52% in relapsed patients, and the longest remission period exceeds 10 a. Intravenous administration is appropriate, does not produce obvious toxic side effects, and there is no cross resistance between other leukemias and other chemotherapeutic drugs. In order to further expand the medicinal value and expand its spectrum and clinical therapeutic spectrum, we discuss the use of arsenic trioxide The inhibition of human hepatocellular carcinoma cell growth and its mechanism provide a theoretical basis for its use in the treatment of liver cancer.1 Materials and methods 1.1 Materials Human hepatocellular carcinoma cell line BEL-7402 was received by teacher Li Hongyuan of Harbin Medical University School of Public Health. University First Clinical