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以大鼠四动脉闭塞造成脑缺血模型研究了脑缺血和再灌注时大鼠40Hz听觉相关电位（40HzAERP）反应阈值、振幅的改变及听力的动态变化。在脑缺血早期；AERP反应阈随缺血时间的延长持续升高，缺血15、3060min与2h组阈值显著高于对照组（P＜0.01），振幅则明显降低，出现急性听力下降。再灌注初期2h听反应阈保持较高水平，与缺皿30min比较无统计学差异（P＞1.05）再灌注24、48、72h反应阈值逐渐下降，仍有明显的听力报失。再灌注7天后听阈基本恢复，但振幅下能恢复正常。结果提示40HzAERP对缺血非常敏感,脑缺血和再灌注可能导致突发性听力损伤。
The rat model of cerebral ischemia induced by occlusion of the four arteries was used to study the changes of the threshold and amplitude of 40 Hz AERP and the dynamic changes of hearing in rats with cerebral ischemia and reperfusion. In the early stage of cerebral ischemia, the response threshold of AERP continued to increase with the prolongation of ischemia, and the threshold of 15,60Omin and 2h was significantly higher than that of the control group (P <0.01). The amplitude of AERP was significantly decreased and acute hearing loss occurred. The response threshold kept at a high level at 2h after reperfusion, and there was no significant difference between the two groups (P> 1.05) at 24 and 48h after reperfusion. After 7 days of reperfusion, the threshold was basically recovered, but the amplitude returned to normal. The results suggest that 40 Hz AERP is very sensitive to ischemia, and cerebral ischemia and reperfusion may lead to sudden hearing loss.