七情致病理论及其防治是中医病因病机学中的一个重要内容 ,但目前相关研究较少 ,现代医学中的心理应激理论与中医七情学说在认识上存在着许多共同点 ,从应激角度出发 ,结合中医“怒伤肝”的理论 ,以束缚制动作为应激原 ,复制慢性激怒应激反应大鼠模型 ,并探讨调肝方药 (ＴＧＦ The theory of seven-pathogenic diseases and its prevention and treatment are an important part of the etiology and pathogenesis of TCM, but there are few related researches. There are many common points in the understanding of psychological stress theory and TCM theory in modern medicine. From the stress point of view, combined with the theory of “anger liver” of Chinese medicine, using restraint brake as a stressor, replicate the rat model of chronic irritative stress, and discuss the prescription of Tiaogan (TGF)