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以苄氧羰基保护的L-脯氨酸和硝基苯胺类化合物为起始原料,通过酰胺化反应和脱苄氧羰基反应,合成了两个结构新颖的N-硝基苯基脯氨酰胺类催化剂,其结构经请下载后查看，本文暂不支持在线获取查看简介。1HNMR、~(13)CNMR和HR-ESI-MS确证。该类催化剂用于环己酮与硝基烯烃的不对称Michael加成反应,其中化合物(S)-N-(2-甲氧基-4-硝基苯基)脯氨酰胺催化所得产物具有优异的收率(82%)、较高的非对映体比例(94∶6 dr)和一定的对映选择性(21%e.e.)。
Benzyloxycarbonyl-protected L-proline and nitroanilines were used as starting materials to synthesize two novel N-nitrophenylproline amides by amidation and debenzyloxycarbonyl reaction Catalyst, the structure of the download, please view, this article does not support online access to view profile. 1H NMR, ~ (13) CNMR and HR-ESI-MS. The catalysts are used for the asymmetric Michael addition reaction of cyclohexanone with nitroalkenes wherein the compound (S) -N- (2-methoxy-4-nitrophenyl) prolinamide catalyzes the resulting product with excellent (82%), higher diastereomer ratio (94: 6 dr) and a certain enantioselectivity (21% ee).