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关于中枢胆囊收缩素(CCK)的研究开始于1975年,Vanderhaegher首先发现大鼠脑内存在胃泌素样免疫活性物质。次年Dockray等在此基础上证实脑内的胃泌素样物质就是CCK,1980年Dockray等又进一步证明脑内的CCK主要是含硫的羧基末端八肽
Research on central cholecystokinin (CCK) began in 1975 and Vanderhaegher first found that gastrin-like immunoreactive substances are present in the rat brain. The following year, Dockray et al. Confirmed that the brain gastrin-like substance was CCK on the basis of this. Dockray et al. Further proved that CCK in brain in the following year was mainly sulfur-containing carboxy-terminal octapeptide