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目的:比较米索前列醇舌下及直肠给药两种给药途径预防产后出血的疗效。方法:72例自然分娩产妇随机分为两组,每组36例,舌下组在胎儿前肩娩出后立即给予米索前列醇600μg舌下含化;直肠组则给予米索前列醇600μg深部肛塞。比较两组产妇在产后2 h、24 h的出血量及用药前后的心率和血压变化,观察用药后的不良反应。结果:产后2h、24 h,舌下组阴道出血量和产后出血发生率均显著低于直肠组(P<0.05)。两组用药前后心率和血压的变化及不良反应发生率差异无统计学意义(P>0.05),但舌下组寒战发生率显著高于直肠组(P<0.05)。结论:米索前列醇舌下含化用于预防自然分娩产后出血,效果显著,安全便捷,值得在临床上推广。
OBJECTIVE: To compare the efficacy of misoprostol administered both sublingually and rectally to prevent postpartum hemorrhage. Methods: Seventy-two cases of spontaneous labor were randomly divided into two groups (36 cases in each group). The sublingual group received sublingual 600μg misoprostol immediately after the anterior shoulder was delivered. The rectal group received misoprostol 600μg deep anal Plug The two groups of maternal postpartum 2 h, 24 h of bleeding and before and after treatment of heart rate and blood pressure changes observed after treatment of adverse reactions. Results: The amount of vaginal bleeding and the incidence of postpartum hemorrhage in sublingual group were significantly lower than those in rectal group at 2 h and 24 h postpartum (P <0.05). There was no significant difference in heart rate and blood pressure and the incidence of adverse reactions between the two groups before and after treatment (P> 0.05), but the incidence of chills in the sublingual group was significantly higher than that in the rectal group (P <0.05). Conclusion: Sublingual misoprostol is used to prevent postpartum hemorrhage of natural childbirth. The effect is obvious, safe and convenient, which is worth to be popularized clinically.