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目的:研究透脓散对浅部化脓性炎症血中性粒细胞FC受体、C3b受体、C5a与局部愈合情况的影响,探讨透脓散与透托法扶正托毒的作用机理。方法:将Wistar大鼠分为病模对照组、透脓散高、中、低剂量组、头孢拉定组,采用金黄色葡萄球菌局部注射致大鼠背部浅部化脓性炎症模型,分别给予相应药物灌胃,观察脓肿愈合情况,于3、6、9 d取血检测血中性粒细胞FC受体、C3b受体与C5a。结果:透脓散可促进脓肿愈合;给药9 d,透脓散组可降低中性粒细胞比值,恢复至正常水平,且明显优于病模对照组与头孢拉定组;透脓散组能明显升高中性粒细胞C3b受体水平,且给药6 d,明显优于头孢拉定组;给药3 d,透脓散组能明显升高中性粒细胞FC受体水平;并且可以影响血C5a水平,具有双向调节作用,炎症早中期降低C5a水平,炎症中后期升高C5a水平。结论:透脓散可促进脓肿愈合,降低中性粒细胞比值,促进炎症消退;升高中性粒细胞C3b、FC受体水平,促进中性粒细胞黏附与吞噬,双向调节血中C5a水平。
OBJECTIVE: To study the effect of perianone powder on neutrophils FC receptor, C3b receptor, C5a, and local healing in patients with superficial purulent inflammation, and to explore the mechanism of penetrating pus and supporting thoracic poisoning. METHODS: Wistar rats were divided into disease control group, penetrating high-, medium-, low-dose group, and cefradine group. The model of suppurative pyogenic inflammation in the back of rats was induced by local injection of Staphylococcus aureus and the corresponding drugs were given respectively. In the stomach, the healing of abscess was observed. Blood was taken at 3, 6 and 9 days to detect the blood neutrophil FC receptor, C3b receptor and C5a. RESULTS: Permeability could promote the healing of abscess; after 9 days of administration, KJS group could reduce the ratio of neutrophils to normal level, and it was obviously superior to the control group and cephradine group; Elevated neutrophil C3b receptor levels, and administered 6 d, significantly better than the cephradine group; 3 days after drug administration, perinexin group can significantly increase the level of neutrophils FC receptor; and can affect blood C5a levels, With two-way adjustment, C5a levels were decreased in the early and middle stages of inflammation, and C5a levels were increased in the middle and later stages of inflammation. Conclusion: Permeability can promote the healing of abscess, reduce the ratio of neutrophils, promote the regression of inflammation, increase the level of C3b, FC receptor in neutrophils, promote the adhesion and phagocytosis of neutrophils, and regulate the levels of C5a in blood bidirectionally.