Study on the classification of chronic gastritis at molecular biological level

来源 :World Journal of Gastroenterology | 被引量 : 0次 | 上传用户:sondenaclaire3
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AIM:To explore the pathophysiologibasis for the fact thatpatients with digestive tract symptoms do not necessarilyhave gastric mucosal pathology and those without clinicalsymptoms do not necessarily have no gastric mucosalpathology.METHODS:The ultrastructure,trace elements,cAMP,DNA,SOD and LPO in the gastric mucosa and its epithelial cells of188 patients without organic lesions of heart,lung,liver,gallbladder,pancreas,kidney or intestine and basicallyhistopathological normal persons (F) were detectedsynchronously by SEM,TEM,EDAX,Image analysis systemRIA and ~3H-TdR Lymphocyte Transfer Test.RESULTS:The content of Zn,Cu,cAMP and ~3H-TdR LCT ingastric mucosa and the content of Zn,Cu,DNA and LPO ingastric mucosa epithelial nuclei of each group were shownas belows:Normal control (4.1±1.0,5.2±0.8,15.9±1.5,1079.7±227.4,7.6±0.4,58.4±0.3,12.6±2.7,2.6±0.6);CSGwithout symptoms group (3.7±1.2,5.1±1.8,15.6±0.9,924.5±234.9,7.8±0.3,58.6±0.4,13.0±3.1,2.9±0.4);CAGwithout symptoms group (3.3±1.0,4.8±0.9,14.9±0.7,887.7±243.6,7.8±0.3,58.7±0.3,14.3±2.8,3.1±0.4);Ftype with symptoms group (3.5±1.4,4.5±1.0,15.7±1.4,932.1±2449.3,7.9±0.4,58.7±0.5,13.5±4.6,2.9±0.7);CSG with symptoms group (2.8±1.9,4.0±1.5,14.2±1.8,867.3±240.5,8.1±0.5,58.9±0.5,15.2±3.2,4.2±0.7);CAG withsymptoms group (2.0±1.8,3.4±1.5,13.4±1.8,800.9±221.8,8.6±0.4,59.3±0.5,16.5±3.1,4.5±0.6).The contents ofZn,Cu in mitochonondria and SOD in gastric mucosa ofeach group were shown as belows:Normal control group(9.2±0.5,58.3±0.3,170.5±6.1),CSG without symptomsgroup (8.9±0.5,58.2±0.3,167.2±5.3),CAG withoutsymptoms group (8.8±0.4,57.5±0.2,166.1±4.2);F type withsymptoms group (8.9±0.5,58.0±0.3,167.9±5.7),CSG withsymptoms group (8.6±0.5,57.8±0.3,163.3±5.6);CAG withsymptoms group (8.3±0.4,57.5±0.3,161.2±4.3).There weresignificant differences in these cases,P<0.05-0.001.Therewere synchronous changes of gastric mucosa epithelialcellular ultrastructure.The“background lesions”(focalatrophic gastritis,focal intestinal metaplasia,micro-ulcer) innonfocal gastric mucosa of all groups had significantdifferences (P<0.05-0.001).CONCLUSION:Disease with symptoms,disease withoutsymptoms,nondisease with symptoms occur on the basis of the quantitative changes of gastric mucosa epithelialcellular ultrastructure and related bioactive substances. AIM: To explore the pathophysiologibasis for the fact that patients with digestive tract symptoms do not necessarily gastric gastric mucosal pathology and those without clinical conditions do not necessarily have no gastric mucosal pathology. METHODS: The ultrastructure, trace elements, cAMP, DNA, SOD and LPO in the gastric mucosa and its epithelial cells of188 patients without organic lesions of heart, lung, liver, gallbladder, pancreas, kidney or intestine and basic histopathological normal persons (F) were detected synchronously by SEM, TEM, EDAX, Image analysis systemRIA and ~ 3H-TdR Lymphocyte Transfer Test.RESULTS: The content of Zn, Cu, cAMP and ~ 3H-TdR LCT ingastric mucosa and the content of Zn, Cu, DNA and LPO ingastric mucosa epithelial nuclei of each group shown below below: Normal control (4.1 ± 1.0, 5.2 ± 0.8,15.9 ± 1.5,1079.7 ± 227.4,7.6 ± 0.4,58.4 ± 0.3,12.6 ± 2.7,2.6 ± 0.6); CSGwithout symptoms groups (3.7 ± 1.2,5.1 ± 1.8,15.6 ± 0.9,924.5 ± 234.9,7.8 ± 0.3, 58.6 ± 0.4, 13.0 ± 3.1, 2.9 ± 0.4); CAGwithout symptoms groups (3.3 ± 1.0,4.8 ± 0.9,14.9 ± 0.7,887.7 ± 243.6,7.8 ± 0.3,58.7 ± 0.3,14.3 ± 2.8,3.1 ± 0.4); Ftype with symptoms group (3.5 ± 1.4,4.5 ± 1.0,15.7 ± 1.4 , 932.1 ± 2449.3, 7.9 ± 0.4, 58.7 ± 0.5, 13.5 ± 4.6, 2.9 ± 0.7); CSG with symptoms group (2.8 ± 1.9,4.0 ± 1.5,14.2 ± 1.8,867.3 ± 240.5,8.1 ± 0.5,58.9 ± 0.5 , 15.2 ± 3.2, 4.2 ± 0.7); CAG with psychological groups (2.0 ± 1.8, 3.4 ± 1.5, 13.4 ± 1.8, 800.9 ± 221.8, 8.6 ± 0.4, 59.3 ± 0.5, 16.5 ± 3.1, 4.5 ± 0.6) , Cu in mitochondria and SOD in gastric mucosa of achive groups were shown as below: Normal control group (9.2 ± 0.5, 58.3 ± 0.3, 170.5 ± 6.1), CSG without symptoms group (8.9 ± 0.5, 58.2 ± 0.3, 167.2 ± 5.3) CAG without symptoms group (8.8 ± 0.4, 57.5 ± 0.2, 166.1 ± 4.2), F type with symptoms group (8.9 ± 0.5, 58.0 ± 0.3, 167.9 ± 5.7), CSG with symptoms group (8.6 ± 0.5, 57.8 ± 0.3, 163.3 ± 5.6 ); CAG withsymptoms group (8.3 ± 0.4, 57.5 ± 0.3, 161.2 ± 4.3). Thereweresignificant differences in these cases, P <0.05-0.001.Therewere synchronous changes of gastric mucosa epithelialcellular ultrastructure.The “background lesions ”(focalatrophic gastritis, focal intestinal metaplasia, micro-ulcer) innonfocal gastric mucosa of all groups had significant differences (P <0.05-0.001). CONCLUSION: Disease with symptoms, disease without symptoms, nondisease with symptoms occur on the basis of the quantitative changes of gastric mucosa epithelialcellular ultrastructure and related bioactive substances.
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