Kinase相关论文
背景:50%以上胶质母细胞瘤(Glioblastoma,GBM)中存在表皮生长因子受体(Epidermal growth factor receptor,EGFR)过表达或突变,但EG......
Auxin acts as a key hormone in plant that determines many developmental processes by the typical concentration dependent......
Triple administration of osimertinib followed by chemotherapy for advanced lung adenocarcinoma: A ca
BACKGROUND Osimertinib is the recommended first-line treatment for adult patients with epidermal growth factor receptor(......
The 26S proteasome at the center of the ubiquitinproteasome system (UPS) is essential for virtually all cellular process......
Phosphorylation of the Pseudomonas Effector AvrPtoB by Arabidopsis SnRK2.8 Is Required for Bacterial
A critical component controlling bacterial virulence is the delivery of pathogen effectors into plant cells during infec......
Systematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-
Objective:Osteosarcoma is the most common primary malignant bone tumor. However, the survival of patients with osteosarc......
尽管肌酸激酶(Creatine Kinase)的活性无特异性,诊断价值较小,但诊断心肌梗塞时,血清肌酸激酶的活性测定还是一种常用的方法。不......
The WNK kinases are a recently discovered family of serine-threonine kinases that have been shown to play an essential r......
非受体酪氨酸激酶c-Abl在正常生理及病理条件下具有多种生物学功能。当电离辐射、顺铂、丝裂霉素C等DNA损伤诱导剂诱导DNA损伤反应......
通过构建妊娠合并糖尿病诱发先天性神经管缺陷的SD大鼠模型，与胚胎不伴有先天性神经管缺陷组大鼠和正常对照组大鼠胚胎进行研究，提取......
目的：检测糖原合成酶激酶3β（ GSK3β）、p-GSK3βser9和p-GSK3βTyr216表达水平在宫颈癌组织中的表达情况及其与临床病理因素的相关性......
硒是动物必需的微量元素,硒半胱氨酸是硒蛋白的组份并构成硒酶的活性中心,硒蛋白特别是硒酶是硒的主要功能形式.研究发现,硒半胱氨......
动物宰后其骨骼肌的能量代谢是影响宰后肉品品质的重要因素之一。在动物宰后的糖酵解中,腺苷酸蛋白活化激酶（AMP-activated protein......
植物激素脱落酸(Abscisic acid,ABA)在植物应对生物和非生物胁迫中起着重要作用.本研究利用以carks单基因突变体为亲本,构建双重突......
目的：构建人Polo样激酶1（Plk1）活性缺失突变体及结构域突变体的真核表达载体，并在293细胞中表达。方法：用二次PCR方法扩增Plk1基因并点......
EFFECT OF ACTIVE COMPOUNDS ISOLATED FROM PTERIS SEMIPINNATA L ON DNA TOPOISOMERASES AND TYROSINE PRO
Objective: To study the effect of active compound 6F and A from Pteris semipinnata L.(PsL) on the activities of DNA topo......
Objective: To investigate the expression difference of protein kinase B/Akt (Akt-1) between hepatocellular carcinoma (HC......
Objective: To survey the role of protein tyrosine kinases (PTKs) in the pathogenesis of several hematopoietic malignanci......
采用分子动力学方法研究激酶ABL与ATP位点小分子imatinib、P16及变构位点小分子STJ、MS7、MS9、3YY、MYR等的结合，并用GBSA（generali......
目的：探讨鞘氨醇激酶1（SPHK1）和核因子（NF）-κB在非小细胞肺癌（NSCLC）组织中的表达及其与NSCLC浸润、转移和预后的关系。方法选取93例外科......
激酶组学是近年研究较多的一类组学。激酶的磷酸化在调控细胞代谢和生理进程等方面起到重要作用，但原核生物激酶组学研究存在研究时......
对抑制剂paullones的来源、合成,以及与激酶相互作用的分子机理、选择性、细胞效应进行了综述.指出糖原合成酶激酶-3（GSK-3）是参与糖......
为了解和掌握运动员在冬训前的基本机能和训练情况，2007年11月甘肃省体育科研所对24名甘肃省体工队中长跑运动员进行了在冬训前生理......
目的:探讨从微生物代谢产物中寻找溶栓药物制备的研究方法和动态.方法:从大量的近期文献中阐述了来源于微生物代谢产物溶栓药物的......
目的：克隆并在293细胞中表达人Polo样激酶1（Plk1）基因，探索Plk1对非受体型酪氨酸激酶c-Abl表达水平的影响。方法：利用PCR法扩增Plk1基因......
目的：表达纯化GST-Plk1及GST-Plk1 KD、GST-Plk1 PBD融合蛋白,以用于Plk1与其结合蛋白相互作用的研究。方法：PCR扩增Plk1全长及其KD......
背景与目的：细胞周期蛋白依赖激酶4（cyclin-dependent kinase 4，CDK4）是调控细胞周期进程的重要激酶之一，有实验报道其在子宫内膜癌中呈......
To investigate the effect of lithium on cell cycle progression of airway epithelial cells,primary pig tracheobronchial e......
Pim kinases contribute to tumor formation and development of lymphoma,which shows enhanced DNA replication,DNA recombina......
目的探讨缺氧对孕大鼠肾组织中PKCα表达的影响及当归注射液是否调节其表达而具有保护缺氧孕大鼠肾的作用。方法Wistar孕大鼠随机......
期刊
急性心肌梗死（AMI）是一种常见且严重危及生命的心脏疾病，在欧关一些国家一直是主要的死因之一。近年来在我国有明显增加的趋势。本病......
Plk1是一类从酵母到人类都高度保守的丝氨酸/苏氨酸蛋白激酶。Plk1与不同的细胞周期检查点的精密调控有关,从而确保了细胞周期事件......
运用表皮条生物学分析、激光共聚焦扫描及膜片钳技术,在MEK1/2和p38MAP激酶专一性抑制剂PD98059和SB203580处理下,观察促分裂原活......
Overexpression of Arabidopsis thaliana cysteine2/histidine2-type transcription factor 6 gene enhance
Transcription factors can be used to engineer plants for enhanced productivity.However,the mechanism(s)by which the C2H2......
蛋白质的磷酸化过程是人体内翻译后修饰的重要一步。非正常的磷酸化会导致人体产生各种疾病。近年来，通过分析化学的手段研究磷酸化......
通过在两个具有不同内源性生长抑素受体（SSTR）表达谱的癌细胞系capan-2和A549中过表达SSTR2，用生长抑素类似物（SSA）奥曲肽或者伐普肽（RC-......
目的：探讨ETK调节膀胱癌细胞侵袭转移的分子机制。方法：首先应用Westernblot技术检测ETK在5种膀胱癌细胞中的表达水平,再使用ETKshRN......
目的：研究酪蛋白激酶2α（Ck2α）、β-catenin和 survivin在卵巢癌组织中的表达情况，分析三者在卵巢癌中表达的相关性，探讨其临床应用价......
目的研究心力衰竭（HF）大鼠心肌β3肾上腺素受体（beta3-adrenergic receptors,β3-AR）表达情况及对钙离子相关调节蛋白的作用。方法以正......
Novel Oncogene with Kinase—domain（NOK）是一个新的肿瘤相关基因，其结构上与受体蛋白相似，具有一个蛋白激酶结构域。过量表达NOK会导......
AIM To investigate the effects of herb-partitioned moxibustion(HPM) on phosphorylation of mitogen-activated extracellula......
目的观察精氨酸血管加压素（arginine vasopressin，AVP）抗失血性休克作用与Rho kinase的关系。方法采用大鼠失血性休克模型，整体动物观......
随着人们对于消化道肿瘤的研究逐渐深入,诊断方法和治疗手段需要更加直接和准确.寻找可靠的肿瘤干细胞标志物一直是肿瘤研究中的重......
目的 研究RNA干扰（RNAi）沉默S期激酶相关蛋白2（Skp2）对胃癌细胞侵袭的影响.方法 以胃癌细胞株SGC7901为实验对象,构建、并筛选出以Skp2......
Efficacy of adjuvant tyrosine kinase inhibitor therapy for non-small cell lung cancer and its influe
Objective:To study the efficacy of adjuvant tyrosine kinase inhibitor therapy for non-small cell lung cancer and its inf......
Study on the correlation of MLCK and FAP expression with uterine fibroid cell proliferation and inva
Objective:To study the correlation of myosin light chain kinase (MLCK) and fibroblast activation protein (FAP) expressio......
Assessment of the tumor malignancy after immunotherapy combined with EGFR-TKIs drug treatment of EGF
Objective:To study the effect of immunotherapy combined with epidermal growth factor receptor-tyrosine kinase inhibitors......
Objective:To study the correlation of glycogen synthesis kinase 3β (GSK3β) expression with cell invasion and prolifera......
Correlation of IRAK1 and TRAF6 expression with inflammatory response and immune response in oral lic
Objective: To study the correlation of IRAK1 and TRAF6 expression with inflammatory response and immune response in oral......
Objective: To study the correlation of PI3K/Akt signaling pathway with cell apoptosis and invasion in mantle cell lympho......
