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目的:探讨极低体重早产儿动脉导管未闭(PDA)的治疗方法。方法:本研究回顾性分析6例经外科手术治疗的PDA的极低体重早产儿的临床特点。结果:4例患者布洛芬治疗失败、2例患者因药物禁忌行动脉导管结扎术,术后由对呼吸机依赖转为3～4d过渡脱机,胃肠内喂养耐受性及体重增加显著改善[(45±41)∶(258±77)g/周,P<0.001],5例存活患者均无手术并发症,1例患者死于早产儿并发症。结论:对于有手术指征的PDA的极低体重早产儿,外科手术结扎是安全而有效的方法。
Objective: To investigate the treatment of patent ductus arteriosus (PDA) in very low birth weight infants. Methods: This study retrospectively analyzed the clinical features of 6 preterm infants with very low birth weight who underwent surgical treatment of PDA. Results: The ibuprofen treatment failed in 4 patients and catheterization in 2 patients was contraindicated because of drug taboo. The postoperative transition from reliance on ventilator to 3 ~ 4d transition was offline. The tolerance to gastrointestinal feeding and weight gain were significant (45 ± 41): (258 ± 77) g / week, P <0.001). No complications were found in 5 survivors and 1 patient died of complications in premature infants. Conclusions: Surgical ligation is a safe and effective method for very low birth weight preterm infants with PDA indications.