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目的 :研究股动脉插管 ,术前诱导化疗在舌癌综合治疗中的作用。方法 :对 2例临床分期分别为Ⅲ、Ⅳ期 ,有根治可能性的舌癌患者 ,由股动脉超选择插管至舌动脉 ,然后在 30min内经导管先后注入甲氨喋呤 10 0mg、顺铂 10 0mg、四氢叶酸钙30 0mg与造影剂的混合液及条状明胶海绵。化疗后 14d ,进行疗效评价 ,再施行舌颈联合根治术。结果 :化疗后舌体出现肿胀和疼痛 ,无全身性不良反应 ,临床评价为有效。术后 1年半随访 ,未发现肿瘤复发或转移。结论 :舌癌诱导化疗时采用动脉插管的介入方法 ,结合条状明胶海绵栓塞处理 ,可以提高化疗效果 ,减少不良反应和并发症
Objective: To study the role of femoral artery catheterization and preoperative chemotherapy in the comprehensive treatment of tongue cancer. Methods: Two cases of tongue cancer with clinical stage of Ⅲ and Ⅳ were treated by superselective intubation of the femoral artery to the lingual arteries, and then injected with methotrexate (10 mg, 10 0mg, 300mg of calcium folinate and 30mg of contrast agent mixture and gelatin sponge strip. After 14 days of chemotherapy, the curative effect was evaluated, and the tongue and neck combined radical mastectomy was performed again. Results: After chemotherapy, swelling and pain occurred in the tongue, no systemic adverse reactions, clinical evaluation was effective. After 1 year and half follow-up, no tumor recurrence or metastasis was found. Conclusion: The interventional therapy of arterial cannulation in tongue cancer chemotherapy combined with strip gelatin sponge embolization can improve the curative effect and reduce the adverse reactions and complications