采用蒙特卡罗模拟退火方法对一系列线性五肽进行了构象分析，探索了线性肽的优势构象与其环化产率之间的关系．构象分析所得到的预测结果与实验结果吻合． A series of linear pentapeptides were subjected to conformational analysis using Monte Carlo simulated annealing method to explore the relationship between the dominant conformation of the linear peptide and its cyclization yield. The predicted results obtained by conformational analysis are consistent with the experimental results.