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我们对107例胃腺癌和癌旁腺体的形态改变,结合粘液组织化学和免疫酶组织化学的方法进行了观察,发现不同性质的腺体扩张和组织学类型有关。单纯性腺体扩张见于各种类型的腺癌;异型性腺体扩张多见于管状腺癌。尤其早期管状腺癌出现各级、多量异型腺体扩张,并与管状腺癌的腺体交叉,有向管状腺癌由轻度到重度异型增生上皮过渡的形态。异型性腺体扩张的组织结构、细胞形态、粘液组织化学和免疫酶组织化学都与管状腺癌相一致,只是程度的差异。
We observed morphological changes in 107 cases of gastric adenocarcinoma and paracancerous glands, combined with mucohistochemical and immunoenzymatic histochemical methods, and found that different types of glandular dilation and histological types are involved. Simple glandular expansion is seen in various types of adenocarcinoma; atypical glandular expansion is more common in tubular adenocarcinoma. In particular, early tubular adenocarcinoma developed at various levels and in a large number of abnormal glands, intersecting with the glands of tubular adenocarcinomas, and transitioning from mild to severe dysplastic epithelium to tubular adenocarcinoma. The tissue structure, cell morphology, mucin histochemistry, and immunoenzymatic histochemistry of the atypical glandular expansion were all consistent with the tubular adenocarcinoma, except for the degree of difference.