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胸膜间皮瘤为来源于胸膜间皮细胞的原发性肿瘤,比较少见。Wagner于1870年首先描述一例,称为“结节性淋巴腺瘤”。直到1942年,Stout和Mur-ray运用Maxiwow’s组织培养技术,证明间皮细胞为这种脑膜肿瘤的起源,从此才确立为病理上的单独类型。1967年,世界卫生组织(WHO)把胸膜间皮瘤列为肺部肿瘤的一种组织类型。由于肿瘤在大体及镜下极为多样化,对起源见解不一,故命名混乱,目前已有不同名称30余种,如内皮瘤、内皮癌、肉瘤、癌肉瘤等。胸膜间皮瘤临床表现常与其它胸部肿瘤相似,近50年来才逐渐为人们所重视。
Pleural mesothelioma is a primary tumor derived from pleural mesothelial cells and is rare. Wagner first described an example in 1870, called “tumorous lymphoma.” Until 1942, Stout and Mur-ray used Maxiwow’s tissue culture technology to prove that mesothelial cells were the origin of this type of meningeal neoplasm and it has since been established as a pathologically distinct type. In 1967, the World Health Organization (WHO) classified pleural mesothelioma as a tissue type of lung tumor. Because the tumors are extremely diverse in the general and microscopic view, and there are different views on the origins, the names are confused. There are currently more than 30 different names, such as endothelium, endothelium, sarcoma, carcinosarcoma and so on. The clinical manifestations of pleural mesothelioma are often similar to those of other thoracic tumors, and have only gradually gained importance in the past 50 years.