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我国自八十年代初广泛应用原代地鼠肾细胞狂犬疫苗(PHKC-RV,下称地鼠肾苗)以来,接种者较未接种者的狂犬病死亡率有了明显的降低,而且疫苗无严重的副作用。但是,传统的常规五针接种在14天才陆续产生抗体,45天达到抗体高峰,与近期发病的狂犬病预防不相适应。1987年Rodrigues报道了用人二倍体细胞狂犬疫苗作接触前预防取得了令人满意的效果。为探讨地鼠肾苗作接触前预防的可行性,我们对7年内有地鼠肾苗接种史者进行了1支再免疫(下称再免),用酶联免疫吸附试验(ELISA)
Since the widespread application of primary hamster kidney cell rabies vaccine (PHKC-RV) in China since the early 1980s, rabies mortality has been significantly reduced in vaccinated and non-vaccinated Side effects. However, the conventional routine five-needle inoculation gradually produced antibodies in 14 days and reached the peak of antibody in 45 days, which is incompatible with the recent onset of rabies prevention. In 1987, Rodrigues reported that prophylactic use of diploid cell rabies vaccines achieved satisfactory results. In order to explore the feasibility of prophylaxis of hamster kidney vaccine for pre-exposure, we conducted a re-immunization (hereinafter referred to as re-immunization) of those who had vaccination history of hamster kidney vaccine within 7 years. Enzyme-linked immunosorbent assay (ELISA)