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1以青霉素 G 钾为原料,采用过氧乙酸作氧化剂合成青霉素 G 亚砜2加入 BSU 生成青霉素 G 亚砜硅酯,在HB_r4-甲基吡啶催化下扩环制备头泡 G酸.“,”1 Penici11in G potassium salt can be oxidized by Peraceticacid to give sul foxide 2 The 7-(phenylacetamido)deacetoxy- cephalosporin acid was prepared byring expansion of penicillin G sulfoxide via its trimethylsiliated intermediate(protective silylation with N,N?dimethylsilylurca) using HBr?4?methylpyridine as catalyst.