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Objective:To investigate the anti-proliferative effect of histone deacetylases-1(HDAC-1)knockdown in Hela cells.Methods:The HDAC-1 protein was knockdowned using siRNA.The expression of HDAC-1 was detected by Western blotting.Apoptosis was assessed by flow cytometry.The inhibition of cell growth was assesses by MTT assay.Result:HDAC-1 siRNA knockdowned the expression of HDAC-1 protein.HDAC siRNA inhibited lhe proliferation of Hela cells.HDAC-1 siRNA induced apoptosis.Conclusion:HDAC-1 siRNA may inhibit the growth of Hela cells by inducing apoptosis.