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目的探讨SARS康复者康复后及其1年内血清冠状病毒IgG、IgM抗体的产生水平及动态变化,为该病 的下一步预防和疫苗的保护效力提供依据。方法 采用ELISA法对SARS康复者冠状病毒IgG、IgM抗体进行 检测,对IgG或IgM抗体连续两次检测都为阳性者继续随访1年;对二者连续两次都为阴性者放弃随访;随访结 果用stata 7.0软件分析。结果 81.2％的康复者连续两次IgG抗体检测阳性;18.8％的康复者连续两次IgG抗 体阴性;对311例IgG抗体阳性者进行了1年的随访,除1例在出院后85 d时抗体变为阴性外,其他310例康复 者1年后IgC抗体仍为阳性,但抗体平均水平下降了约35.8％;22例IgG抗体阳性康复者(2003年4月3日-5 月21日出院)进行了IgM抗体检测,2003年5月30日检测时,22.7％的康复者IgM抗体阳性,2003年6月14日 检测时,IgM抗体全为阴性。结论 IgM抗体在康复后短期内很快消失;约有81.2％的康复者能够产生IgG抗 体;1年随访中,除1例康复者IgG抗体由阳性转为阴性外,其他IgG抗体阳性者1年后该抗体仍为阳性,但抗体 水平有所下降。
Objective To investigate the levels and dynamic changes of serum coronavirus IgG and IgM antibodies in SARS convalescent patients after rehabilitation and in 1 year, and provide basis for further prevention and vaccine protective efficacy of SARS convalescent patients. Methods Anti-SARS coronavirus IgG and IgM antibodies were detected by ELISA. Two consecutive positive IgG or IgM antibodies were followed up for one year. The two consecutive follow-up visits were abandoned. Follow-up results Stata 7.0 software analysis. Results 81.2% of the patients were tested positive for IgG antibody twice in a row, 18.8% of the patients were negative for IgG antibody twice in a row, 311 patients were positive for IgG antibody for one year. Except for one case, And the other 310 cases recovered one year after the IgC antibody is still positive, but the average antibody level decreased by about 35.8%; 22 cases of positive IgG antibody-positive patients (April 3, 2003-May 21 discharge) IgM antibody test was carried out. When tested on May 30, 2003, 22.7% of the patients recovered were positive for IgM antibody. On June 14, 2003, IgM antibodies were all negative. Conclusion IgM antibodies disappear rapidly in the short term after recovery. About 81.2% of the patients recovered from IgG antibodies. One year after follow-up, all IgG antibodies positive except 1 patient who recovered from positive to negative were at 1 year After the antibody is still positive, but the antibody levels decreased.