慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一组气流受限为特征的肺部疾病,气流受限不完全可逆,呈进行性发展。它受遗传因素,环境因素以及遗传-环境相互作用的影响。目前,虽然其确切的病因及发病机制不甚明了,但是近年来的研究表明COPD是一种多基因调控的疾病。本文综述了几个较为重要的遗传基因多态性与COPD易感性关系的近期研究进展。 Chronic obstructive pulmonary disease (COPD) is a group of pulmonary diseases characterized by airflow limitation. The airflow limitation is not completely reversible and progresses progressively. It is affected by genetic factors, environmental factors, and genetic-environmental interactions. At present, although its exact etiology and pathogenesis are not clear, recent studies have shown that COPD is a multi-gene regulatory disease. This review summarizes recent advances in the relationship between several of the more important genetic polymorphisms and susceptibility to COPD.