论文部分内容阅读
Gardner等曾成功地用钴治疗肾衰竭贫血,但有明显副作用如厌食、恶心、呕吐和腹泻。这些症状与剂量有关。如给予氯化钻肠溶片每天不超过100毫克,这些副作用就不常见。也有的作者报告副作用轻微,这可能与钻在肠道吸收的差异有关。有些作者研究了靠人工肾维持的病人每天给予25～50毫克氯化钴的疗效。Bowie等给14例患者口服氯化钴水溶液,每天2次,头4周每天25毫克,后4周每天50毫克。前14周红细胞比积变化很小,8周后11例完成治疗的病人红细胞比积增加23％。除3例出
Gardner et al. Have successfully treated anemia of kidney failure with cobalt, but have obvious side effects such as anorexia, nausea, vomiting and diarrhea. These symptoms are dose-related. If given perchloride enteric coated tablets does not exceed 100 mg per day, these side effects are not common. Some authors also reported minor side effects, which may be related to the difference in the absorption of the gut in the gut. Some authors have studied the effect of administering 25-50 mg of cobalt chloride per day to patients on artificial kidney support. Bowie et al 14 oral administration of aqueous cobalt chloride solution, 2 times a day, 25 mg per day for the first 4 weeks and 50 mg per day for the next 4 weeks. In the first 14 weeks, the change of hematocrit was small, and after 11 weeks of treatment, hematocrit increased by 23% in 8 patients. Except 3 cases